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KMID : 0613820060160071214
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Journal of Life Science
2006 Volume.16 No. 7 p.1214 ~ p.1218
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Sedative Effects of Combined Administration of 4-Hydroxy-3-methoxybenzaldehyde, a Component of Gastrodia elata, and 2,3-Dihydroxybenzaldehyde in Rats
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Lee Dong-Woong
Choi Hyoung-Chul
Lee Kwang-Youn
Lee Soo-Kwan
Kim Jung-Ae
Yong Chul-Soon
Kim Jin-Sook
Huh Keun
Shin Son-Moon
Koo Byung-Soo
Ha Jeoung-Hee
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Abstract
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The present study was performed to investigate the sedative effects of the combined administration of phenolic compounds. 4-hydroxy-3-methoxybenzaldehyde, a component of Gastrodia elata, showing positive GABAergic neuromodulation was administered intraperitoneally together with an identical dose of 2,3-dihydroxybenzaldehyde, a potent antioxidant, to the rats and then evaluated for its effects on the convulsion, the hypnosis, the anxiety and the muscle relaxation. Combined administration of both compounds significantly reduced the pentyleneterazole-induced lethality. In addition, this mixture significantly enhanced the pentobarbital-induced sleeping time. Contrary to the anticonvulsive and sedative effects, the combined administration did not exhibit anxiolytic or muscle relaxant activities. These results indicated that the combined treatment of 2,3-dihydroxybenzaldehyde and
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KEYWORD
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Gastrodia elata, sedatives, phenolic compound, combined administration
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